Cooper I, Fridkin M, Shechter Y. Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations. PLoS One. 2016;11(7):e0158352. doi: 10.1371/journal.pone.0158352. PubMed PMID: 27403959.

 

Cooper I, Last D, Guez D, Sharabi S, Elhaik Goldman S, Lubitz I, Daniels D, Salomon S, Tamar G, Tamir T, Mardor R, Fridkin M, Shechter Y, Mardor Y. (2015). Combined local blood-brain barrier opening and systemic methotrexate for the treatment of brain tumors, J Cereb Blood Flow Metab. 2015 Jun;35(6):967-76. 

 

Ruban A, Cohen-Kashi Malina K, Cooper I, Graubardt N, Babakin L, Jona G, and Teichberg VI. (2015). Combined treatment of an ALS rat model with recombinant GOT1 and Oxaloacetic acid: a novel neuroprotective treatment, Neurodegener Dis. 2015;15(4):233-42.

 

Greenbaum L....Cooper I et al. (2015). The Alzheimer's disease risk loci BIN1 is associated with poorer episodic memory performance in cognitively normal Type 2 diabetes elderly. European Neuropsychopharmacology

 

Lubitz I, Ricny J, Atrakchi-Baranes D, Shemesh C, Kravitz E,Liraz-Zaltsman S, Maksin-Matveev A, Cooper I et al. (2016) High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Abeta deposition in an Alzheimer mouse model. Aging Cell.

 

Greenbaum L, Ravona-Springer R, Lutz MW, Heymann A, Lubitz I, Cooper I, Kravitz E, Sano M, Roses AD, Silverman JM, Saunders AM, Beeri MS. (2014). The TOMM40 Poly-T rs10542523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. European Neuropsychopharmacology, 24: 1492-1499.

 

Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS. (2014). Blood methylomic signatures of questionable dementia in elderly subjects with Type 2 Diabetes Mellitus. Neurobiol Aging. 2015 Mar;36(3):1600.e1-4

 

Cooper, I., Sasson, K., Teichberg, V. I., Beeri, M.S., Fridkin, M., and Shechter, Y. (2012) Peptide derived from HIV-1 TAT protein, destabilizes a monolayer of endothelial cells in an in vitro model of the blood-brain barrier, and allows permeation of high molecular weight proteins, J Biol Chem. 28;287(53):44676-83. * Selected for cover.

 

Scherzer-Attali, R., Farfara, D., Cooper, I., Levin, A., Ben-Romano, T., Trudler, D., Vientrov, M., Shaltiel-Karyo, R., Shalev, D. E., Segev-Amzaleg, N., Gazit, E., Segal, D., and Frenkel, D. (2012) Naphthoquinone-tyrptophan reduces neurotoxic Abeta*56 levels and improves cognition in Alzheimer's disease animal model, Neurobiol Dis 46, 663-672.

 

Ruban, A., Berkutzki, T., Cooper, I., Mohar, B., and Teichberg, V. I. (2012) Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas, Invest New Drugs. 30(6):2226-35.

 

Cohen-Kashi-Malina, K., Cooper, I., and Teichberg, V. I. (2012) Mechanisms of glutamate efflux at the blood-brain barrier: involvement of glial cells, J Cereb Blood Flow Metab 32, 177-189.

 

Cooper, I., Cohen-Kashi Malina, K., Cagnotto, A., Bazzoni, G., Salmona, M., and Teichberg, V. I. (2011) Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions, J Neurochem 116, 467-475. * Selected for cover.

 

Cooper, I., Cohen-Kashi-Malina, K., and Teichberg, V. I. (2011) Claudin-5 expression in in vitro models of the blood-brain barrier, Methods Mol Biol 762, 347-354.

 

Cohen-Kashi Malina, K*., Cooper, I*., and Teichberg, V. I. (2009) Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness, Brain Res 1284, 12-21.*Equal contribution.

 

Ganor, Y., Grinberg, I., Reis, A., Cooper, I., Goldstein, R. S., and Levite, M. (2009) Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemia in vivo, Leuk Lymphoma 50, 985-997.

 

Teichberg, V. I., Cohen-Kashi-Malina, K., Cooper, I., and Zlotnik, A. (2009) Homeostasis of glutamate in brain fluids: an accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies, Neuroscience 158, 301-308.

 

Barbara Fellerhoff Losch, Sergiy V. Korol, Yonatan Ganor, Songhai Gu, Itzik Cooper, Raya Eilam, Michal Besser, Meidan Goldfinger, Yehuda Chowers8, Rudolf Wank, Bryndis Birnir and Mia Levite (2015) Normal human CD4+ helper T cells express Kv1.1 voltage-gated K+ channels, and selective Kv1.1 block in T cells induce by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway, J Neural Transm, accepted.